Rare and Autoimmune Blood Disorders

Rare and autoimmune blood disorders include conditions such as autoimmune hemolytic anemia, aplastic anemia, paroxysmal nocturnal hemoglobinuria, and rare clotting factor deficiencies. These disorders arise from genetic mutations, immune system dysregulation, or unknown environmental triggers, leading to destruction or dysfunction of blood cells, impaired hematopoiesis, and clinical complications such as anemia, thrombosis, or bleeding. Diagnostic approaches include complete blood counts, peripheral blood smears, bone marrow evaluation, flow cytometry, immunoassays, and molecular genetic testing. Laboratory instruments such as automated hematology analyzers, flow cytometers, ELISA readers, and sequencing platforms enable precise detection of abnormal cells, autoantibodies, and genetic defects. Clinical management involves immunosuppressive therapies, targeted biologics, blood transfusions, and stem cell transplantation for severe cases. Understanding the underlying biological mechanisms is essential for accurate diagnosis, therapeutic planning, and research into novel treatments. This session provides delegates with a detailed overview of the biology, diagnostic methods, and instrumentation associated with rare and autoimmune blood disorders, enhancing the ability to recognize, study, and manage these complex conditions in clinical practice.

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