Coagulation and Hemostasis Disorders

Coagulation and hemostasis disorders involve abnormalities in the blood clotting process, leading to either excessive bleeding or unwanted clot formation. Hemostasis is a critical physiological process that maintains the balance between bleeding and clotting, involving platelets, coagulation factors, and vascular endothelium. Disorders may include hemophilia, von Willebrand disease, thrombophilia, disseminated intravascular coagulation, and platelet function abnormalities. Biological understanding of these conditions highlights the interplay of coagulation proteins, genetic mutations, and cellular mechanisms affecting clot formation and stability. Diagnostic methods involve coagulation assays such as prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin generation tests, platelet function tests, and factor activity measurements. Advanced laboratory tools include automated coagulation analyzers, flow cytometers, ELISA readers, and molecular genetic testing platforms. These instruments allow precise assessment of clotting factor deficiencies, platelet abnormalities, and thrombotic tendencies. Understanding coagulation pathways is critical for guiding treatment decisions, including replacement therapies with clotting factors, anticoagulant management, and novel therapies like recombinant factor proteins or gene therapy approaches. This session provides delegates with a comprehensive overview of the biological mechanisms underlying hemostasis and coagulation disorders, the diagnostic techniques and instruments used in laboratories, and emerging therapeutic strategies. By integrating biological knowledge with practical diagnostic applications, participants gain insights into optimizing patient management, preventing complications, and advancing clinical practice in hematology and transfusion medicine.

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