16^th Global Summit on Hematology and Infectious Diseases March 02-03, 2020 London, UK

Macromolecular immunoactive polysaccharides, glucans, are now available for the prophylaxis of viral, bacterial or fungal infection. They can gently induct or modify of immunity without hyperstimulation. A successful example of using glucans for anti-viral treatment is the pharmaceutical called Kagocel. It is based on highly standardized chemically modified both natural polyphenol and immunoactive cellulose betaglucan. The commercial success of this drug in the Russian pharmaceutical market is due to its excellent safety and efficacy record over fifteen years. The antiviral efficacy of Kagocel against influenza infection has been confirmed in vitro and in vivo in relation of different strains H3N2 and H1N1 influenza viruses, including H1N1pdm09. In vitro, the antiviral activity of Kagocel has been demonstrated by its effect on the infectious titer of influenza virus, and on the level of expression of viral antigens. Clinical studies have shown that the combined use of Kagocel and Tamiflu significantly reduces the number of complications of influenza infection and reduces the time of recovery. Research and development of this concept, has led to other experimental compositions of immunoactive beta-glucan cellulose and polyphenols with antimicrobial activity. Immunoactive beta-glucan cellulose macromolecules with oseltamivir phosphate, the active pharmaceutical ingredient of Tamiflu, significantly increased the biological activity of oseltamivir phosphate. Chemically modified immunoactive beta-glucans may be very promising objects for the development of

new pharmaceuticals.

Osama A. Shaikhomar has completed his PhD at the age of 43 years from Nottingham University, UK and postdoctoral studies from Umm Al-Qura University School of Medicine. He is the x dean of Faculty of Medicine at the University of Umm Al-Qura. Vice dean of Faculty of Medicine for Academic Affair and Development. Member of the General Committee of the quality and accreditation. Coordinator of Physiology course for 2n year students. Chairman of Physiology department.faculty of Medicine. He has published more than 13 papers in reputed journals and has been serving as an editorial board member of repute.

To examine the association between antiphospholipid antibodies and gestational age of abortion and duration post abortion in Saudi women living in Western region of Saudi Arabia (Makkah) in order to consider the interactive association with major demographic factors. Materials and Methods: In this freeliving population study blood samples were collected from 100 females who had history of spontaneous recurrent abortion as case group and 100 pregnant healthy women as control group ages ranged between 22 and 40 years, with a mean age of 31.4 ± 12.69 years. Serum antiphospholipid antibodies were measured.

Results: Average rate of antiphospolipid antibodies in the serum of case group compared with the control group indicated no significant statistical difference. In case group the number of miscarriages were more, mean of antiphosopolipid antibody levels were also higher. Mean antiphospholipid antibodies rate was greater with increasing gestational age at time of first miscarriage. Almost mean antipospholipid antibodies in all patients remained in high level just in first 4 years with any number of miscarriages and 4 years later, antibodies began to fall. Conclusion: The results of the present study demonstrated that antiphospholipid antibodies based on number of miscarriages and gestational age of miscarriages were increased. More over mean antipospholipid antibodies in all patients remained in high level just in first 4 years post miscarriage and then began to fall. However, well-designed diagnostic studies are needed to estimate the true association between other specific autoantibodies and recurrent miscarriage through epidemiological studies with a

larger sample size, including different age groups and populations.